Plaza 600 is centrally located with frontage on Stewart, 6th Ave, and Westlake Avenue, between the Retail Core and the South Lake Union neighborhood. Its location provides convenient access to I-5 and mass transit, including the King Country metro, Sound Transit express busses, Link Light Rail, South Lake Union Streetcar (located directly across the street), and the Monorail at Westlake Center. Major employers in the area include Amazon HQ, Google, Nordstrom, and Facebook.